Anthropic’s Claude models in Microsoft Foundry now run on NVIDIA GB300 Blackwell Ultra GPUs, and the real news isn’t just the hardware — it’s that NVIDIA integrated a hardware-level governance layer that lets enterprises run autonomous agents without handing over the keys to the kingdom.
What the GB300 NVL72 Brings to Agentic Inference
Claude in Foundry runs on NVIDIA GB300 NVL72 systems with Quantum-X800 InfiniBand networking. That cluster delivers the raw compute needed for agentic AI — think autonomous sub-agents that coordinate across business domains, not just single-turn chat. Inference performance and efficiency drive total cost of ownership, and the GB300’s architecture is built for that.
Hardware-Enforced Governance for Autonomous Agents
NVIDIA’s Secure Agent Workspace Reference Design is the centerpiece. It provides a blueprint for running autonomous agents in a governed environment where identity, network access, credentials, and runtime policy are controlled at the infrastructure level. That means an enterprise can let a Claude agent act on its behalf — query databases, hit APIs, manipulate files — without worrying about credential leaks or lateral movement. The agent gets a hardware-enforced identity, not a shared service account.
NVIDIA’s Verified Agent Skills Tie Claude to Enterprise Workflows
Through NVIDIA verified agent skills — enabled by access to NVIDIA accelerated computing — enterprises can embed Claude agents deeply into their business processes. These skills give Claude domain-specific abilities that go beyond general reasoning, turning the model into a specialized operator. And because the skills run on the same GB300 hardware with the same governance controls, they inherit the security posture.
This is the three-way partnership between NVIDIA, Anthropic, and Microsoft — announced in November — delivering a concrete, production-ready product. Enterprises can now treat AI agents as first-class, governed system components. NVIDIA just set the bar for what a hardware-accelerated agent platform looks like.
Source: Claude Meets Blackwell Ultra: Anthropic's Models Now Run on NVIDIA GB300 in Azure
Domain: blogs.nvidia.com
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